Plenary 01

Abstracts:

• RESULTS OF THE TREATMENT EVALUATION OF ACUTE STROKE USING REGENERATIVE CELLS (TREASURE) CLINICAL TRIAL
• EARLY RHYTHM-CONTROL THERAPY FOR ATRIAL FIBRILLATION IN PATIENT WITH HISTORY OF STROKE IN THE EAST-AFNET 4 TRIAL
• FACTOR XIA INHIBITOR MILVEXIAN FOR SECONDARY STROKE PREVENTION: RESULTS OF THE AXIOMATIC-SSP PHASE 2 TRIAL
• EFFECTS OF ORAL FACTOR XIA INHIBITOR ASUNDEXIAN ON INCIDENT COVERT BRAIN INFARCTS ACCORDING TO SIZE, LOCATION AND MULTIPLICITY IN ACUTE NON-CARDIOEMBOLIC ISCHEMIC STROKE: PACIFIC-STROKE TRIAL

Plenary 02

Abstracts:

• TENECTEPLASE VERSUS ALTEPLASE IN STROKE PATIENTS WITH LARGE VESSEL OCCLUSION: RESULTS FROM THE ACT TRIAL
• TENECTEPLASE IMPROVES REPERFUSION ACROSS THE SPECTRUM OF LYSIS TO ANGIOGRAPHY TIMES: A POOLED ANALYSIS OF THE MELBOURNE STROKE REGISTRY, EXTEND-IA, AND EXTEND-IA TNK TRIALS
• MULTICENTER RANDOMIZED CLINICAL TRIAL OF ENDOVASCULAR TREATMENT OF ACUTE ISCHEMIC STROKE IN THE NETHERLANDS FOR LATE ARRIVALS: MR CLEAN-LATE
• DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR ACUTE ISCHAEMIC STROKE – INDIVIDUAL PATIENT DATA META-ANALYSIS OF SIX RANDOMIZED CLINICAL TRIALS.
• FINAL ANGIOGRAPHIC, CLINICAL AND THROMBUS COMPOSITION RESULTS OF THE EXCELLENT REGISTRY

Plenary 03

Abstracts:

• THE SECOND ENHANCED CONTROL OF HYPERTENSION AND THROMBECTOMY STROKE STUDY (ENCHANTED2) RANDOMIZED CONTROLLED TRIAL RESULTS
• DUAL THROMBOLYTIC THERAPY WITH MUTANT PRO-UROKINASE AND SMALL BOLUS ALTEPLASE FOR ISCHEMIC STROKE (DUMAS)
• THE PREVALENCE AND PENETRANCE OF MONOGENIC SMALL VESSEL STROKE VARIANTS IN 450,000 UK BIOBANK PARTICIPANTS

Plenary 04

Abstracts:

• GLOBAL DISTRIBUTIONS OF AGE- AND SEX-RELATED ARTERIAL STIFFNESS: SYSTEMATIC REVIEW AND META-ANALYSIS OF 167 STUDIES WITH 509743 PARTICIPANTS
• ASSOCIATION OF INTRAVENTRICULAR FIBRINOLYSIS WITH CLINICAL OUTCOMES IN PATIENTS WITH INTRACEREBRAL HEMORRHAGE: AN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS
• A RANDOMIZED MULTICENTER STUDY TO DETERMINE THE EFFICACY OF SOVATELTIDE (TYCAMZZI™) IN PATIENTS WITH CEREBRAL ISCHEMIC STROKE
• THE INFLUENCE OF EXPERIENCE IN THE MECHANICAL THROMBECTOMY PROCEDURE ON OUTCOMES OF PATIENTS IN THE RESILIENT TRIAL – COMPARISON BETWEEN ROLL-IN AND RANDOMIZED PATIENTS

Late Breaking Clinical Trials I

Abstracts:

• MULTIMORBIDITY IN STROKE IN SPRINT INDIA TRIAL
• MODERATE-INTENSITY ROSUVASTATIN PLUS EZETIMIBE VERSUS HIGH-INTENSITY ROSUVASTATIN FOR LDL-C REDUCTION IN RECENT ISCHEMIC STROKE; A RANDOMIZED CONTROLLED TRIAL (ROSETTA-STROKE)
• LATE ANTICOAGULATION IS ASSOCIATED WITH INCREASED NUMBER OF ISCHEMIC LESIONS IN ATRIAL FIBRILLATION RELATED STROKE: THE ATTUNE TRIAL
• EFFECT OF TIME TO INTRAVENOUS THROMBOLYSIS ON CLINICAL OUTCOMES WITH TENECTEPLASE VS. ALTEPLASE: RESULTS FROM THE ACT PHASE 3 RANDOMIZED CONTROLLED TRIAL
• ATTICUS RANDOMIZED CONTROLLED TRIAL – RESULTS OF PRE-SPECIFIED SECONDARY ANALYSES

Late Breaking Clinical Trials II

Abstracts:

• ECONOMIC EVALUATION OF AN INDIVIDUALISED MANAGEMENT PROGRAM AFTER STROKE
• EFFICACY AND SAFETY OF TENECTEPLASE IN MODERATE AND SEVERE ISCHEMIC STROKE: A POOLED ANALYSIS OF RANDOMIZED CLINICAL TRIALS – NOR-TEST 1 & 2

Debate 1

Presentation Titles:

• A Single Covert Brain Infarction – An Incidental Finding or Opportunity for Prevention?
• Should Double Antiplatelet Be Given Routine for a Short Period for All Non-AF Ischemic Stroke Patients (DAPT)?

Debate 2

Presentation Titles:

• Which Is the Better Strategy for Primary and Secondary Stroke Prevention- Tailored to the Individual or Use of Polypill Concept?
• Is Medical Treatment Enough for Patients With Asymptomatic Severe Cervical Carotid Stenosis?

Debate 3

Presentation Titles:

• Should Intra-Arterial Thrombolysis Be Considered Following Mechanical Thrombectomy With Suboptimal Recanalization?
• Mechanical Thrombectomy for Patients With Large Infarcts (Aspects 3–5), Yay or Nay?

Debate 4

Presentation Titles:

• Left Atrial Appendage Closure Is the Main Treatment Option for Patients With AF Who Have Had A Stroke Despite Optimal Anticoagulation?
• Is there an optimal time or time sensitive window after stroke to enhance motor recovery?

Debate 5

Presentation Titles:

• Is Perfusion Imaging for Decision Making for Reperfusion Treatment in Patients With Large Vessel Obstruction in the Late Time Window Essential or Not Worth the Hassle?
• Low-Dose Alteplase for Stroke Thrombolysis – Is the Clinical Role Defined?

Debate 6

Presentation Titles:

• Should Patients on a Direct Oral Anticoagulant Within the Last 48 Hours Be Excluded From Thrombolysis, or Should Testing and Reversal Be Considered?
• Is the preferred management of carotid web surgery?

Stroke in the COVID-19 pandemic

Presentation Titles:

• Pathophysiology and outcomes of stroke associated with COVID-19 infection
• Impact of COVID-19 on stroke care- early experience from the breakout in Wuhan
• Hyperacute recanalization stroke treatments in COVID-19 patients
• Stroke rehabilitation in a pandemic – Limitations and opportunities

Diagnostic and Predictive Biomarkers in Stroke and Cognitive Impairment

Presentation Titles:

• The role of biomarkers in acute stroke management
• Biomarkers to guide secondary stroke prevention
• Biomarkers of high-risk carotid and intracranial atherosclerosis
• Biomarkers and the risk of dementia

Latest approaches to ICH management

Presentation Titles:

• Comparison of 2022 ICH guideline: ESO and AHA/ASA
• Latest data on blood pressure management in ICH
• Advances in neurosurgical ICH approaches
• Recent issues of oral anticoagulant associated ICH
• Anticoagulation after ICH – considerations for patients with AF, cerebral microbleeds and others

Advance in Intracranial Artery Stenosis (ICAS) and Clinical Practice

Presentation Titles:

• Stroke syndromes and mechanisms related to ICAS
• Advances in imaging for ICAS
• Hyperacute treatment for stroke-related to ICAS
• Secondary prevention for stroke secondary to ICAS

Retrieving the clot – achieving the task 

Presentation Titles:

• Aspiration versus Stent Retriever Thrombectomy – When to use which?
• How clot imaging could help thrombectomy?
• Thrombectomy-resistant large vessel obstruction stroke- tricks and tips
• Adjunctive Intra-arterial thrombolysis optimizing reperfusion

New Avenues for Secondary stroke prevention

Presentation Titles:

• Factor XIa inhibition: what is the rational in context of secondary stroke prevention
• Lp(a) a new potentially treatable target in secondary stroke prevention
• Intensive lipid control and tighter target levels for secondary stroke prevention
• Anti-inflammatory targets for secondary stroke prevention

Updates on stroke primary and secondary prevention

Presentation Titles:

• Antiplatelets including role of dual antiplatelet therapy
• Anticoagulation and device therapy for structural heart disease
• Carotid disease- medical management and carotid intervention
• Blood pressure control: Is intensive lowering necessary?

Disparities in stroke epidemiology and care

Presentation Titles:

• Stroke in Women: What we all should know in 2022
• Racial and ethnic disparities in stroke: novel insights
• Digital health innovations to reduce inequities in stroke
• Impact of country and region economic status

Hyper-acute therapies of ischemic stroke

Presentation Titles:

• Intravenous thrombolysis prior to mechanical thrombectomy- a critical review of the evidence
• Lesson learnt from meta-analysis of RCT for thrombolysis and mechanical thrombectomy
• Intravenous thrombolysis prior to mechanical thrombectomy: Application in the real world.

SEA session – Current status and plans to improve stroke care in Southeast Asia- developing a legacy following WSC 2022.

Presentation Titles:

• Stroke epidemiology & working towards a common data repository
• Acute stroke services and opportunities to improve care
• Stroke nursing across the region and potential collaborations
• Stroke recovery and advocacy- gaps and opportunities
• Developing a roadmap for stroke care across the region

Big picture issues affecting stroke

Presentation Titles:

• Environmental and climate change & Stroke
• Ageing paradigms & Brain, Vascular disease
• Neuroplasticity and stroke recovery
• Stem cells – the opportunity for stroke

Emerging Topics in Atrial Fibrillation and Stroke

Presentation Titles:

• What’s New With Anticoagulation and Atrial Fibrillation?
• Rhythm Control in Patients With AF for Stroke Prevention
• Screening for Atrial Fibrillation: When, How, and in Whom?
• Atrial Fibrillation and Cognitive Impairment

Joint Session with World Health Organization (WHO) – Salient Considerations for Implementation of interventions for reducing the global burden of stroke.

Presentation Titles:

• Policy and Pragmatic Solutions to improve global surveillance of stroke and its risk factors
• Policy and Pragmatic Solutions to improve Primary and Secondary Prevention of stroke
• Policy and Pragmatic Solutions to improve hyperacute and acute stroke care
• Policy and Pragmatic Solutions to improve rehabilitation and re-integration of stroke survivors
• Discussion: Bringing these elements together for scaling up stroke prevention and control globally

Joint Session with World Federation of Neurology (WFN) – Challenges in Stroke Education

Presentation Titles:

• Challenges of stroke education in African- WFN needs registry
• Regional differences in stroke education, training, and awareness
• World Stroke Academy Activities and Special Projects
• The Future Stroke Leaders programme
• Family centred post stroke education: primary and secondary prevention.

Joint Session with World Hypertension League (WHL) – The Global Use of Stroke as an Indicator of Population Hypertension Control

Presentation Titles:

• Stroke and Hypertension Outcomes in Sub-Saharan Africa
• Stroke and Hypertension Outcomes in Brazil and South America
• Stroke and Hypertension Outcomes in Asia
• Roadmap and overall global plan for hypertension

Joint Session with Chinese Stroke Association (CSA) – Reperfusion strategies for stroke

Presentation Titles:

• Advances of Tenecteplase Treatment for Reperfusion
• TRACE trials: Tenecteplase reperfusion therapy in acute ischemic cerebrovascular events I, II, and III
• Automated stroke perfusion evaluation software
• A topic on endovascular therapy (title pending)

Joint Session with The Association of Southeast Asian Nations Neurological Association (ASNA) – Stroke patterns and issues in Asian

Presentation Titles:

• Stroke and infections
• Thrombolysis and small vessel disease
• Clopidogrel resistance in secondary stroke prevention
• Radiation associated carotid disease

Joint Session with Middle East North Africa Stroke and Interventional Neurology (MENA-SINO) and
Middle East North Africa Stroke Association (MENASO) – Stroke Services Organization in the Middle East Region

Presentation Titles:

• Utilization of Technology To Improve Stroke Care in LMICs in the MENA Region
• Stroke and Neurointervention Training Challenges & Improvement Strategies in the MENA Region
• Improving Stroke Research and Increasing Research Outputs in the MENA Region
• Standardising Stroke Services in the MENA Region

Joint Session with The Society of Vascular and Interventional Neurology (SVIN) – Interventional Stroke Neurology

Presentation Titles:

• Clinical Trials in Large Vessel Obstruction Stroke Treatment – What We Have Learnt and How To Move Forward
• 10 Years of Mechanical Thrombectomy – Implications on Stroke Treatment and Impact of Clotology
• Evolution of Neuroimaging for Mechanical Thrombectomy
• Mechanical Thrombectomy- a Global Overview and Gaps in Implementation
• Medical Management With Mechanical Thrombectomy

Joint Session with Asia Pacific Stroke Organisation (APSO) – Stroke in Asia

Presentation Titles:

• Challenges of stroke care during the COVID-19 pandemic, especially in Asia
• Embolic Stroke of Unknown Source – treatment in Asians
• Stroke aetiologies in Asians
• Stroke care systems in Asia

Joint Session with The International Society of Vascular Behavioural and Cognitive Disorders (VasCog) – Advances in Vascular Cognitive Impairment and Dementia

Presentation Titles:

• Post-stroke cognitive impairment and dementia: what have we learned from previous studies and what will DISCOVERY reveal
• Diagnosing vascular cognitive impairment
• Dementia risk models in stroke cohorts
• Brain imaging for vascular cognitive impairment – what is useful and what needs to be established
• How should we perform better clinical trials globally for vascular cognitive impairment?

Joint Session with ISRRA
Implementation Science – Bridging the Gap Between Research and Practice

Presentation Titles:

• What To Implement? Selecting Best Stroke Practices Using Consensus-Based Guidelines
• How To Implement? Supporting and Sustaining the Implementation of Best Stroke Practices
• Lessons Learnt From Implementing Evidence-Based Stroke Care in Low-/Middle-Income Countries
• Building Partnerships With Industry and Academic/Research Centres

TC 1: Challenging Stroke Cases (180 min)

Presentation Titles:

• Vascular Eagle Syndrome and TIA
• Fabry Disease and Stroke
• Bone Disease and Stroke
• Moya Moya Disease
• Cancer-Associated Stroke
• Stroke in Sickle Cell Disease
• Cerebral Amyloid Angiopathies Related to Inflammation

TC 2: Pediatric Ischemic Stroke

Presentation Titles:

• Stroke Etiologies & Treatments
• Pediatric Stroke Thrombectomy: Workflow Variations Around the World
• Imaging of Pediatric Ischemic Stroke
• The Australian Paediatric Acute Code Stroke (PACS) Study – Mark Mackay (SSO Talk; Possible Lived Experience Sharing)

TC 3: Imaging Concepts in Stroke

Presentation Titles:

• Imaging for Haemorrhagic Stroke – From Basic to Advanced
• Quick Imaging Assessment for Reperfusion Decision Making
• Imaging of Cerebral Vasculature Including Vessel Wall Imaging
• Perfusion and Collaterals

TC 4: Post Stroke Complications (180 min)

Presentation Titles:

• Seizures and Epilepsy
• Post Stroke Pain and Spasticity- When To Suspect and Treatment Modalities
• Neuropsychiatric Complications of Stroke
• Issues With Sexuality and Intimacy
• Fatigue
• Movement Disorders
• Long Term Emotional Well-Being (SSO)

TC 5: Rare Genetic Causes of Stroke When To Search for Them

Presentation Titles:

• Genetic Risk Factors for Ischemic and Hemorrhagic Stroke
• Genetics of Aneurysms and SAH
• Monogenic Cerebral Small-Vessel Diseases
• Mitochondrial Disease and Stroke

TC 6: Neurosonology From Basics to Latest News

Presentation Titles:

• High Risk Carotid Plaques – Assessing for Risk Beyond Severity of Stenosis
• Potential Role of Microemboli Monitoring in Stroke Management
• Cerebrovascular Reactivity and Perfusion Imaging Using TCD
• Right to Left Shunting With cTCD, cTTE and cTEE
• When and Which Modality To Use in Stroke Evaluation

TC 7: Primary Angiitis of the Central Nervous System & Cerebral Dissection

Presentation Titles:

• The Many Faces of PACNS: Clinical Presentation and Diagnostic Work-Up
• The Fine Art of PACNS Treatment: From Easy to Tough Cases
• Cerebral Artery Dissection- Clinical Presentation and Diagnostic Work-Up
• Treatment Options and Duration for Cerebral Dissection

TC 8: Breadth of Nursing in Stroke Care

Presentation Titles:

• Hyperacute Stroke Care With and Without Reperfusion Treatment
• Stroke Unit Management Is Key in Both Low and High Resource Settings
• Outpatient Care of Stroke Patients – Scope and Opportunities
• Role of Nurses in Support and Advocacy for the Stroke Community
• Sharing by Person With Lived Experience on Their Stroke Journey and How Nurses Made a Difference

TC 9: Diagnosis and Management of Cerebral Venous Thrombosis

Presentation Titles:

• Introduction to CVST: What We Know and Are Still Learning About?
• Epidemiology of CVST
• Diagnosis and Management of Cerebral Venous Thrombosis
• Cerebral Venous Thrombosis in Women

TC 10: Hyperacute Stroke

Presentation Titles:

• Simulation Training for Mechanical Thrombectom
• The History of Thrombolysis From NINDS Trial To Present
• EVT for Non-Interventionalists- Show and Tell
• Reversal of Anticoagulation for Thrombolysis Treatment
• Neuroprotection – Where Does It Stand in the Reperfusion Era?

TC 11: How to Implement Acute Stroke Care: From the Hospital to the Country 

Presentation Titles:

• Evaluating your service or potential services – The WSO Roadmap for quality of Stroke Services
• Structuring your stroke unit and stroke team: what elements are important?
• Creating the stroke care pathways, implementing reperfusion therapy
• Why and how to monitor the quality?
• How to discuss with health managers to organize stroke care?

Case-Based Discussion

• Moderate discussions with an interactive platform of interesting stroke dilemmas